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Project Details
  • Title: The role of glial fate determinants in the generation of astrocytomas
  • Date Proposed: 02/11/2009
  • Amount Requested: $40,000.00
  • Amount we Paid: $40,000.00
  • Paid Date: 04/09/2009
  • Stauts: Funded - and in progress!
  • Research name: Benjamin Deneen Ph.D
  • Hospital: Baylor College of Medicine
  • Grey Ribbon Crusade Participants:
    • Musella Foundation For Brain Tumor Research & Information, Inc
    • The Nick Gonzales Foundation for Brain Tumor Research
  • Simple Description: Lay Summary In both adults and children, astrocytomas are the most common and deadly form of brain cancer. Astrocytomas are derived from glial cells, which make up the support matrix of the brain. Many of the mechanisms that control the generation of glial cells have been identified and are found in astrocytomas. Therefore, the goal of this proposal is to determine whether the processes that control the generation of glial cells are important for the generation of astrocytomas. In previous studies we identified a gene called Nuclear Factor I-A (NFIA) that controls the generation of glial cells and is also found in astrocytomas. In preliminary studies, elimination of NFIA from human and mouse astrocytoma cell lines blocked tumor formation. In this study we want to utilize stem cell models of astrocytoma to determine the exact genetic conditions that are necessary for NFIA to promote tumor formation. The ultimate goal of these studies is to determine whether manipulation of the processes responsible for the generation of glial cells can be utilized in the treatment of astrocytomas. The studies outlined in this proposal are the first step in the development of a clinically relevant, biologically based therapy.