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Project Details
  • Title: Radiosensitization of medulloblastoma by altering the intracellular redox environment with microRNA 128a
  • Date Proposed: 08/26/2009
  • Amount Requested: $65,000.00
  • Amount we Paid: $0.00
  • Paid Date: 01/01/2000
  • Stauts: Approved - Waiting For Funding
  • Research name: Sujatha Venkataraman PhD
  • Hospital: Univ. of Colorado at Denver
  • Grey Ribbon Crusade Participants:
    • Musella Foundation For Brain Tumor Research & Information, Inc
  • Simple Description: The goal of this project entitled” Radiosensitization of medulloblastoma by altering the intracellular redox environment with microRNA 128a” is to enhance radiosensitivity of medulloblastoma, a pediatric brain tumor, to low dose radiation and thereby to reduce radiation-related morbidity. This can be done by carefully integrating microRNAs into radiation signaling pathway and thereby altering the redox status of cancer stem cells. This in turn will enhance the radio sensitivity of cancer stem cells and therefore patients can be treated with low dose radiation. Reducing the dose of radiation to normal brain tissue will reduce the side effects of radiation and therefore maintain adequate survival.